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KMID : 0869619950120010037
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Journal of Korean Society of Hospital Pharmacists
1995 Volume.12 No. 1 p.37 ~ p.40
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Content Uniformity and Dissolution Rate of Carbamazepine CR Tablets
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Abstract
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Drug effect depend on bioavailability of preparation and also bioavailability is largely depend on dissolution rate and content uniformity. This study was attempted to evaluate bioavailability of preparations for drug choice among preparations by dissolution test and content uniformity test of commercial carbamazepine CR tablets. Carbamazepine is given by mouth in the treatment epilepsy. It dose-related adverse effects include dizziness, drowsiness, ataxia and visual disturbances. The dissolution test was conducted in artificial gastric juice using Basket method with three carbamazepine CR(controlled released) preparations(A, B, C) which were pharmaceutically equivalent. The results were as following:1) The dissolution rate in artificial gastric juice was higher in the order of three different brands C>A>B. 2) Content uniformity of three different brands was better in such order as B>A>C. The relationship between each results was not established.
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